L-A-glycerophosphorylcholine CAS 28319-77-9

Chemical Name: L-A-glycerophosphorylcholine

CAS: 28319-77-9

Assay: 99.0% min

Molecular formula:C8H20NO6P

Molecular weight:257.22

EINECS: 248-962-2

L-A-glycerophosphorylcholine  Properties

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L-A-glycerophosphorylcholine  Application and Synthesis

Chemical Property: Glycerophosphorylcholine (GPC) is miscible with water, soluble in methanol and ethanol, insoluble in chloroform, ether, oil, etc., and has no characteristic absorption under ultraviolet and visible light. GPC content determination methods include high performance liquid chromatography (equipped with evaporative light scattering detector or refractive index differential detector) and digestion phosphorus method.

Usage 1: Glycerophosphorylcholine has been listed in Italy, Poland, Greece, Chile, South Korea, Brazil, Russia and other countries. It not only provides the high levels of choline needed by brain cells and nerve cells, but also protects their cell walls. Patients with Alzheimer's disease mainly show decline in memory and cognitive function, and are accompanied by a variety of complications, such as functional impairments such as inconvenient movement and nervous system disorders. Clinical pharmacological test results and clinical trials have confirmed that glycerophosphorylcholine is of great help to the cognitive ability and memory function of the brain.

Usage 2 : Glycerophosphorylcholine can delay the decline of memory, and it is suitable for the rehabilitation and prevention of patients with cerebral apoplexy, cranial and brain injury. The cell membrane of the human brain is damaged due to aging, and the situation will be improved when the synthesis of acetylcholine and phosphatidylcholine in the body increases. Glycerophosphorylcholine can enter the lipoprotein structure, and it can be administered not only orally but also intravenously. Pharmacokinetic studies have proved that glycerophosphorylcholine can be absorbed in intravenous injection and small intestine, and then enter various organs through blood circulation, and bind lipoprotein in the liver. It also has a certain effect on the growth of adolescents, protecting the liver, anti-rheumatoid, improving the cognitive ability of the elderly, anti-arteriosclerosis, resisting fat penetration of high-fat protein foods, and improving memory.

Usage 3 : Digestive System Drugs/Adjuvant Drugs for Liver Diseases

Production Method:

 1) At 25°C and -0.09MPa, slowly add 140g of phosphoric acid dropwise (the drop rate is 10 drops/s) to 100g of choline chloride crude product (containing 70% choline chloride), after the dropwise addition is completed The temperature was raised to 70°C for vacuum distillation until there was no distilled water, then the temperature was raised to 120°C and the pressure was controlled at -0.09MPa to react for 6h, and then 50g of water was added to terminate the reaction to obtain a phosphorylcholine chloride mixture;

2) At 25° C., mix 100 g of the above-mentioned phosphorylcholine chloride mixture with 3000 g of calcium hydroxide aqueous solution (the mass fraction of calcium hydroxide is 15%) for 10 min until the pH of the system reaches 8 to obtain a metathesis mixture;

3) At 25°C and 35Pa, the above-mentioned metathesis mixture was subjected to vacuum distillation until the solid was precipitated to obtain a solid-liquid mixture;

4) Cool the above solid-liquid mixture to -5°C for crystallization for 40 minutes, then filter and dry at 100°C for 2 hours to obtain 100 g of phosphorylcholine chloride calcium salt tetrahydrate (purity: 100%);

5) The filtered filtrate was recrystallized at -5°C for 40 minutes, then filtered and dried at 100°C for 2 hours to obtain phosphorylcholine chloride calcium salt tetrahydrate.